Top N.I.H. Official Abruptly Resigns as Trump Orders Deep Cuts

The No. 2 official at the National Institutes of Health abruptly resigned and retired from government service on Tuesday, in another sign that the Trump administration is reshaping the nation’s public health and biomedical research institutions.

The official, Dr. Lawrence A. Tabak, a dentist and researcher, was long considered a steadying force and had weathered past presidential transitions. In a letter that Dr. Tabak sent to colleagues on Tuesday, he did not give a reason for his decision. One person familiar with the decision said Dr. Tabak had been confronted with a reassignment that he viewed as unacceptable.

“It has been an enormous privilege to work with each of you (and your predecessors) to support and further the critical NIH mission,” Dr. Tabak wrote.

Dr. Tabak resigned at a turbulent time for the institutes, the nation’s premier biomedical research industry, composed of 27 separate institutes and centers that study and develop treatments for diseases like cancer and heart conditions as well as infectious diseases like AIDS and Covid. The N.I.H. spends roughly $48 billion a year on medical research, much of it in grants to medical centers, universities and hospitals across the country.

President Trump’s decision to slash billions of dollars in N.I.H. grant funding has sparked a bitter court battle. And the Senate on Wednesday voted to advance the nomination of Robert F. Kennedy Jr., a vaccine skeptic and the president’s pick for secretary of the Department of Health and Human Services, which oversees the N.I.H.

Mr. Kennedy has said he would cut 600 N.I.H. jobs.

The N.I.H. said it would soon have a statement about Dr. Tabak’s decision.

Dr. Tabak was not well-known to the public. But his decision to leave is surprising, and destabilizing for an agency that is on the political hot seat. He was viewed as someone who could work across party lines; he had survived the presidential turnovers of both parties and had indicated he expected to stay on after Mr. Trump was elected in November.

Ordinarily, Dr. Tabak would have ascended to the job of acting N.I.H. director during the transition from one administration to the next. But the Trump administration installed another researcher, Matthew Memoli of the National Institute of Allergy and Infectious Diseases, as acting director. Dr. Memoli criticized Covid vaccine mandates, as did Mr. Kennedy.

As acting director of the N.I.H. last year, Dr. Tabak pushed back against Republicans’ assertions that a lab leak stemming from U.S. taxpayer-funded research might have caused the coronavirus pandemic. He told lawmakers that viruses being studied at a laboratory in Wuhan, China, bore no resemblance to the one that set off the world’s worst public health crisis in a century.

Ellen Barry contributed reporting.